Drug interactions
Cyclizine + Lisdexamfetamine
Severity: Minor
Cyclizine and Lisdexamfetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine is a sedating antihistamine with anticholinergic activity, and the stimulant may counter its drowsiness. The clinical effect is small and usually manageable.
What this interaction means in plain words
Cyclizine and Lisdexamfetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclizine belongs to Respiratory; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Opposing CNS effects of an antihistamine and a stimulant.
What to do
No specific action is required. Monitor for tachycardia if anticholinergic effects are prominent.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Lisdexamfetamine?
MediHelp rates the interaction as minor. Cyclizine and Lisdexamfetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclizine is a sedating antihistamine with anticholinergic activity, and the stimulant may counter its drowsiness. The clinical effect is small and usually manageable.
How serious is the interaction between Cyclizine and Lisdexamfetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is required. Monitor for tachycardia if anticholinergic effects are prominent.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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