Drug interactions
Cyclobenzaprine + Givosiran
Severity: Moderate
Cyclobenzaprine and Givosiran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can inhibit CYP1A2, and cyclobenzaprine is partly cleared via CYP1A2. Exposure to cyclobenzaprine may rise, increasing drowsiness, anticholinergic effects and other adverse effects.
What this interaction means in plain words
Cyclobenzaprine and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Givosiran belongs to Miscellaneous.
Why it happens
Givosiran inhibits CYP1A2, reducing cyclobenzaprine metabolism.
What to do
Consider a lower cyclobenzaprine dose or an alternative muscle relaxant. Monitor for sedation and anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Cyclobenzaprine with Givosiran?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran can inhibit CYP1A2, and cyclobenzaprine is partly cleared via CYP1A2. Exposure to cyclobenzaprine may rise, increasing drowsiness, anticholinergic effects and other adverse effects.
How serious is the interaction between Cyclobenzaprine and Givosiran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower cyclobenzaprine dose or an alternative muscle relaxant. Monitor for sedation and anticholinergic effects.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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