Drug interactions
Cyproheptadine + Hawthorn
Severity: Minor
Cyproheptadine and Hawthorn: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hawthorn is reported to have mild sedative properties, so combination with a sedating antihistamine could add to drowsiness. Evidence is limited and largely theoretical.
What this interaction means in plain words
Cyproheptadine and Hawthorn have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyproheptadine belongs to Respiratory; Hawthorn belongs to Gastrointestinal Tract.
Why it happens
Possible additive sedative effect; the mechanism is not well established.
What to do
Advise patients to watch for excess drowsiness and avoid driving if affected. No dose change is routinely needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Hawthorn
- Amiodarone + Hawthorn Moderate
- Digoxin + Hawthorn Moderate
- Disopyramide + Hawthorn Moderate
- Encainide + Hawthorn Moderate
- Hawthorn + Ibutilide Moderate
- Hawthorn + Procainamide Moderate
Frequently asked questions
Can I take Cyproheptadine with Hawthorn?
MediHelp rates the interaction as minor. Cyproheptadine and Hawthorn have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hawthorn is reported to have mild sedative properties, so combination with a sedating antihistamine could add to drowsiness. Evidence is limited and largely theoretical.
How serious is the interaction between Cyproheptadine and Hawthorn?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to watch for excess drowsiness and avoid driving if affected. No dose change is routinely needed.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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