Drug interactions
Digoxin + Hawthorn
Severity: Moderate
Digoxin and Hawthorn: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hawthorn has positive inotropic and vasodilating properties and could theoretically add to digoxin's effects. It may also interfere with digoxin assays or levels, but the evidence is limited. Together they could increase the risk of bradycardia or arrhythmia.
What this interaction means in plain words
Digoxin and Hawthorn can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Hawthorn belongs to Gastrointestinal Tract.
Why it happens
Possible additive inotropic and cardiac effects; not firmly established.
What to do
Avoid routine combined use if possible; if used together, monitor heart rate, ECG and digoxin levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Hawthorn
- Amiodarone + Hawthorn Moderate
- Disopyramide + Hawthorn Moderate
- Encainide + Hawthorn Moderate
- Hawthorn + Ibutilide Moderate
- Hawthorn + Procainamide Moderate
- Hawthorn + Propranolol Moderate
Frequently asked questions
Can I take Digoxin with Hawthorn?
MediHelp rates the interaction as moderate. Digoxin and Hawthorn can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hawthorn has positive inotropic and vasodilating properties and could theoretically add to digoxin's effects. It may also interfere with digoxin assays or levels, but the evidence is limited. Together they could increase the risk of bradycardia or arrhythmia.
How serious is the interaction between Digoxin and Hawthorn?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combined use if possible; if used together, monitor heart rate, ECG and digoxin levels.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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