Drug interactions
Dacomitinib + Duloxetine
Severity: Moderate
Dacomitinib and Duloxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib strongly inhibits CYP2D6 and can raise exposure to CYP2D6 substrates such as duloxetine. Duloxetine is also metabolized by CYP1A2, which limits the effect, but increased adverse effects may occur.
What this interaction means in plain words
Dacomitinib and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dacomitinib belongs to Oncology; Duloxetine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6-mediated duloxetine metabolism by dacomitinib.
What to do
Monitor for duloxetine adverse effects including nausea, dizziness, hypertension and serotonin toxicity, and reduce the dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Dacomitinib with Duloxetine?
MediHelp rates the interaction as moderate. Dacomitinib and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dacomitinib strongly inhibits CYP2D6 and can raise exposure to CYP2D6 substrates such as duloxetine. Duloxetine is also metabolized by CYP1A2, which limits the effect, but increased adverse effects may occur.
How serious is the interaction between Dacomitinib and Duloxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for duloxetine adverse effects including nausea, dizziness, hypertension and serotonin toxicity, and reduce the dose if they occur.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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