Drug interactions
Dacomitinib + Methamphetamine
Severity: Moderate
Dacomitinib and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib is a strong CYP2D6 inhibitor and may raise methamphetamine concentrations. This could increase hypertension, tachycardia and CNS stimulation.
What this interaction means in plain words
Dacomitinib and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dacomitinib belongs to Oncology; Methamphetamine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6-mediated methamphetamine metabolism by dacomitinib.
What to do
Monitor blood pressure, heart rate and stimulant effects, and lower the methamphetamine dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Dacomitinib with Methamphetamine?
MediHelp rates the interaction as moderate. Dacomitinib and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dacomitinib is a strong CYP2D6 inhibitor and may raise methamphetamine concentrations. This could increase hypertension, tachycardia and CNS stimulation.
How serious is the interaction between Dacomitinib and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and stimulant effects, and lower the methamphetamine dose if toxicity appears.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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