Drug interactions
Dacomitinib + Mirtazapine
Severity: Minor
Dacomitinib and Mirtazapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib strongly inhibits CYP2D6, which is one of the enzymes metabolizing mirtazapine. Mirtazapine levels may rise modestly, but it is metabolized by several pathways, so the clinical effect is expected to be limited.
What this interaction means in plain words
Dacomitinib and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dacomitinib belongs to Oncology; Mirtazapine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by dacomitinib reduces part of mirtazapine metabolism.
What to do
No routine change is needed. Monitor for increased sedation or other adverse effects of mirtazapine and reduce the dose if they appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Dacomitinib with Mirtazapine?
MediHelp rates the interaction as minor. Dacomitinib and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dacomitinib strongly inhibits CYP2D6, which is one of the enzymes metabolizing mirtazapine. Mirtazapine levels may rise modestly, but it is metabolized by several pathways, so the clinical effect is expected to be limited.
How serious is the interaction between Dacomitinib and Mirtazapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor for increased sedation or other adverse effects of mirtazapine and reduce the dose if they appear.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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