Drug interactions
Dacomitinib + Risperidone
Severity: Moderate
Dacomitinib and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib strongly inhibits CYP2D6, the main enzyme converting risperidone to 9-hydroxyrisperidone. Risperidone concentrations may rise, increasing the risk of extrapyramidal symptoms, sedation and hypotension, although the active moiety changes less than the parent drug alone.
What this interaction means in plain words
Dacomitinib and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dacomitinib belongs to Oncology; Risperidone belongs to Central Nervous System.
Why it happens
Dacomitinib inhibits CYP2D6, reducing risperidone metabolism.
What to do
Monitor for extrapyramidal symptoms, sedation and orthostatic hypotension. Consider reducing the risperidone dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Dacomitinib with Risperidone?
MediHelp rates the interaction as moderate. Dacomitinib and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dacomitinib strongly inhibits CYP2D6, the main enzyme converting risperidone to 9-hydroxyrisperidone. Risperidone concentrations may rise, increasing the risk of extrapyramidal symptoms, sedation and hypotension, although the active moiety changes less than the parent drug alone.
How serious is the interaction between Dacomitinib and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, sedation and orthostatic hypotension. Consider reducing the risperidone dose if adverse effects appear.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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