Drug interactions
Dacomitinib + Tramadol
Severity: Moderate
Dacomitinib and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib is a strong CYP2D6 inhibitor. Tramadol requires CYP2D6 to form its active O-desmethyl metabolite, so inhibition raises parent tramadol and reduces opioid analgesia, while increasing serotonergic and seizure risk from the parent drug.
What this interaction means in plain words
Dacomitinib and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dacomitinib belongs to Oncology; Tramadol belongs to Musculoskeletal.
Why it happens
Inhibition of CYP2D6-mediated conversion of tramadol to O-desmethyltramadol.
What to do
Monitor for reduced analgesia and for serotonergic or seizure effects, and consider a non-CYP2D6-dependent analgesic. Review the need for tramadol during dacomitinib therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Dacomitinib with Tramadol?
MediHelp rates the interaction as moderate. Dacomitinib and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dacomitinib is a strong CYP2D6 inhibitor. Tramadol requires CYP2D6 to form its active O-desmethyl metabolite, so inhibition raises parent tramadol and reduces opioid analgesia, while increasing serotonergic and seizure risk from the parent drug.
How serious is the interaction between Dacomitinib and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced analgesia and for serotonergic or seizure effects, and consider a non-CYP2D6-dependent analgesic. Review the need for tramadol during dacomitinib therapy.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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