Drug interactions
Dacomitinib + Trimipramine
Severity: Major
Dacomitinib and Trimipramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib strongly inhibits CYP2D6, which contributes to trimipramine clearance. Trimipramine concentrations may rise, increasing anticholinergic, sedative, cardiac conduction and QT effects.
What this interaction means in plain words
Dacomitinib and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dacomitinib belongs to Oncology; Trimipramine belongs to Central Nervous System.
Why it happens
Dacomitinib inhibits CYP2D6-mediated metabolism of trimipramine.
What to do
Avoid if possible, or start with a reduced trimipramine dose and titrate to response. Monitor for tricyclic toxicity and consider ECG and plasma level monitoring.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dacomitinib and Trimipramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Dacomitinib with Trimipramine?
MediHelp rates the interaction as major. Dacomitinib and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dacomitinib strongly inhibits CYP2D6, which contributes to trimipramine clearance. Trimipramine concentrations may rise, increasing anticholinergic, sedative, cardiac conduction and QT effects.
How serious is the interaction between Dacomitinib and Trimipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, or start with a reduced trimipramine dose and titrate to response. Monitor for tricyclic toxicity and consider ECG and plasma level monitoring.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
