Drug interactions
Dacomitinib + Vortioxetine
Severity: Moderate
Dacomitinib and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib is a strong CYP2D6 inhibitor and vortioxetine is cleared primarily by CYP2D6. Vortioxetine exposure may therefore rise considerably, increasing nausea and other dose-related adverse effects. Serotonergic toxicity is a theoretical concern at higher levels.
What this interaction means in plain words
Dacomitinib and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dacomitinib belongs to Oncology; Vortioxetine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6 by dacomitinib reduces vortioxetine clearance.
What to do
Consider reducing the vortioxetine dose by about half while dacomitinib is taken, as for other strong CYP2D6 inhibitors. Return to the original dose after dacomitinib is stopped and its inhibition has resolved.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Dacomitinib with Vortioxetine?
MediHelp rates the interaction as moderate. Dacomitinib and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dacomitinib is a strong CYP2D6 inhibitor and vortioxetine is cleared primarily by CYP2D6. Vortioxetine exposure may therefore rise considerably, increasing nausea and other dose-related adverse effects. Serotonergic toxicity is a theoretical concern at higher levels.
How serious is the interaction between Dacomitinib and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the vortioxetine dose by about half while dacomitinib is taken, as for other strong CYP2D6 inhibitors. Return to the original dose after dacomitinib is stopped and its inhibition has resolved.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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