Drug interactions
Dalteparin + Vortioxetine
Severity: Moderate
Dalteparin and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vortioxetine, like other serotonergic antidepressants, can impair platelet function by depleting platelet serotonin. When combined with dalteparin, the risk of bleeding, especially gastrointestinal, may be increased.
What this interaction means in plain words
Dalteparin and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dalteparin belongs to Cardiovascular; Vortioxetine belongs to Central Nervous System.
Why it happens
Serotonin reuptake inhibition reduces platelet serotonin and aggregation, adding to the anticoagulant effect of dalteparin.
What to do
Monitor for signs of bleeding and check hemoglobin if the combination is continued. Consider gastroprotection in patients with additional bleeding risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Dalteparin with Vortioxetine?
MediHelp rates the interaction as moderate. Dalteparin and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vortioxetine, like other serotonergic antidepressants, can impair platelet function by depleting platelet serotonin. When combined with dalteparin, the risk of bleeding, especially gastrointestinal, may be increased.
How serious is the interaction between Dalteparin and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and check hemoglobin if the combination is continued. Consider gastroprotection in patients with additional bleeding risk factors.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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