Drug interactions
Danicopan + Loperamide
Severity: Moderate
Danicopan and Loperamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-gp and can increase exposure to P-gp substrates such as loperamide. Higher loperamide levels may lead to central opioid effects, constipation and QT prolongation.
What this interaction means in plain words
Danicopan and Loperamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Loperamide belongs to Gastrointestinal Tract.
Why it happens
P-gp inhibition by danicopan increases loperamide absorption and CNS penetration.
What to do
Use the lowest effective loperamide dose and avoid exceeding labeled limits. Monitor for sedation, constipation and palpitations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loperamide
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Loperamide?
MediHelp rates the interaction as moderate. Danicopan and Loperamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-gp and can increase exposure to P-gp substrates such as loperamide. Higher loperamide levels may lead to central opioid effects, constipation and QT prolongation.
How serious is the interaction between Danicopan and Loperamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective loperamide dose and avoid exceeding labeled limits. Monitor for sedation, constipation and palpitations.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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