Drug interactions
Danicopan + Lovastatin
Severity: Moderate
Danicopan and Lovastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-glycoprotein and may raise concentrations of P-gp substrates such as lovastatin. Higher statin exposure increases the risk of myopathy and rhabdomyolysis.
What this interaction means in plain words
Danicopan and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Lovastatin belongs to Cardiovascular.
Why it happens
Danicopan inhibits intestinal P-glycoprotein efflux, increasing lovastatin absorption and exposure.
What to do
Monitor for muscle pain, weakness or elevated CK, and consider a lower lovastatin dose or an alternative statin if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Lovastatin?
MediHelp rates the interaction as moderate. Danicopan and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-glycoprotein and may raise concentrations of P-gp substrates such as lovastatin. Higher statin exposure increases the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Danicopan and Lovastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain, weakness or elevated CK, and consider a lower lovastatin dose or an alternative statin if symptoms occur.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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