Drug interactions
Danicopan + Nitrofurantoin
Severity: Minor
Danicopan and Nitrofurantoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits BCRP and can raise exposure to BCRP substrates. Nitrofurantoin is a BCRP substrate, so levels may increase modestly, with limited clinical consequence for short courses.
What this interaction means in plain words
Danicopan and Nitrofurantoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Danicopan belongs to Miscellaneous; Nitrofurantoin belongs to Anti Bacterial.
Why it happens
Inhibition of BCRP-mediated efflux by danicopan raises nitrofurantoin absorption.
What to do
No routine adjustment is needed. Monitor for nitrofurantoin adverse effects, especially with renal impairment or prolonged use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Danicopan and Nitrofurantoin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Nitrofurantoin
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Nitrofurantoin?
MediHelp rates the interaction as minor. Danicopan and Nitrofurantoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danicopan inhibits BCRP and can raise exposure to BCRP substrates. Nitrofurantoin is a BCRP substrate, so levels may increase modestly, with limited clinical consequence for short courses.
How serious is the interaction between Danicopan and Nitrofurantoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for nitrofurantoin adverse effects, especially with renal impairment or prolonged use.
What other medicines interact with Nitrofurantoin?
MediHelp also lists interactions of Nitrofurantoin with, for example, Pexidartinib, Pretomanid, Aluminum hydroxide. The full list is on the Nitrofurantoin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
