Drug interactions
Danicopan + Paliperidone
Severity: Moderate
Danicopan and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-glycoprotein and can increase exposure to P-gp substrates such as paliperidone. Higher paliperidone levels may increase extrapyramidal symptoms, sedation and QT prolongation.
What this interaction means in plain words
Danicopan and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Paliperidone belongs to Central Nervous System.
Why it happens
P-gp inhibition by danicopan reduces paliperidone efflux and clearance.
What to do
Monitor for paliperidone adverse effects and consider a dose reduction if they emerge. Obtain an ECG if other QT-prolonging risks exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Paliperidone?
MediHelp rates the interaction as moderate. Danicopan and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-glycoprotein and can increase exposure to P-gp substrates such as paliperidone. Higher paliperidone levels may increase extrapyramidal symptoms, sedation and QT prolongation.
How serious is the interaction between Danicopan and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for paliperidone adverse effects and consider a dose reduction if they emerge. Obtain an ECG if other QT-prolonging risks exist.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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