Drug interactions
Danicopan + Pravastatin
Severity: Moderate
Danicopan and Pravastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-gp and may increase pravastatin plasma concentrations. Higher exposure could raise the risk of muscle-related adverse effects.
What this interaction means in plain words
Danicopan and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Pravastatin belongs to Cardiovascular.
Why it happens
Danicopan inhibits P-glycoprotein (and possibly BCRP), raising pravastatin exposure.
What to do
Monitor for myalgia and consider a lower pravastatin dose if symptoms appear; check CK when indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pravastatin
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Pravastatin?
MediHelp rates the interaction as moderate. Danicopan and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-gp and may increase pravastatin plasma concentrations. Higher exposure could raise the risk of muscle-related adverse effects.
How serious is the interaction between Danicopan and Pravastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for myalgia and consider a lower pravastatin dose if symptoms appear; check CK when indicated.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
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