Drug interactions
Danicopan + Rimegepant
Severity: Moderate
Danicopan and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-glycoprotein and may increase concentrations of P-gp substrates such as rimegepant. Higher rimegepant exposure could raise the risk of adverse effects.
What this interaction means in plain words
Danicopan and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Rimegepant belongs to Central Nervous System.
Why it happens
Danicopan inhibits P-glycoprotein efflux, raising rimegepant absorption and plasma concentrations.
What to do
Avoid a second rimegepant dose within 48 hours when used with danicopan, in line with guidance for P-gp inhibitors. Monitor for rimegepant adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rimegepant
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Rimegepant?
MediHelp rates the interaction as moderate. Danicopan and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-glycoprotein and may increase concentrations of P-gp substrates such as rimegepant. Higher rimegepant exposure could raise the risk of adverse effects.
How serious is the interaction between Danicopan and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid a second rimegepant dose within 48 hours when used with danicopan, in line with guidance for P-gp inhibitors. Monitor for rimegepant adverse effects.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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