Drug interactions
Danicopan + Rosuvastatin
Severity: Moderate
Danicopan and Rosuvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan increases exposure to BCRP substrates such as rosuvastatin. The higher exposure may increase the risk of myopathy and rhabdomyolysis.
What this interaction means in plain words
Danicopan and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Rosuvastatin belongs to Cardiovascular.
Why it happens
Danicopan inhibits BCRP, reducing efflux of rosuvastatin and increasing systemic exposure.
What to do
Consider reducing the rosuvastatin dose in line with its labeling and monitor for muscle pain, weakness or dark urine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosuvastatin
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Rosuvastatin?
MediHelp rates the interaction as moderate. Danicopan and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan increases exposure to BCRP substrates such as rosuvastatin. The higher exposure may increase the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Danicopan and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the rosuvastatin dose in line with its labeling and monitor for muscle pain, weakness or dark urine.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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