Drug interactions
Danicopan + Saxagliptin
Severity: Moderate
Danicopan and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-glycoprotein and can raise plasma concentrations of P-gp substrates. Saxagliptin is a P-gp substrate, so its exposure may increase, though saxagliptin has a fairly wide safety margin.
What this interaction means in plain words
Danicopan and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Saxagliptin belongs to Endocrine.
Why it happens
Danicopan inhibits intestinal P-gp efflux, increasing saxagliptin absorption.
What to do
Monitor for saxagliptin adverse effects such as hypoglycemia, pancreatitis symptoms and peripheral edema; reduce the dose if tolerability issues appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Saxagliptin?
MediHelp rates the interaction as moderate. Danicopan and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-glycoprotein and can raise plasma concentrations of P-gp substrates. Saxagliptin is a P-gp substrate, so its exposure may increase, though saxagliptin has a fairly wide safety margin.
How serious is the interaction between Danicopan and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for saxagliptin adverse effects such as hypoglycemia, pancreatitis symptoms and peripheral edema; reduce the dose if tolerability issues appear.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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