Drug interactions
Danicopan + Sofosbuvir-velpatasvir-voxilaprevir
Severity: Moderate
Danicopan and Sofosbuvir-velpatasvir-voxilaprevir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-gp and BCRP and can raise plasma concentrations of sofosbuvir, velpatasvir and voxilaprevir, which are substrates of these transporters. Higher exposure may increase the risk of adverse effects from the hepatitis C regimen.
What this interaction means in plain words
Danicopan and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
Why it happens
Danicopan inhibits intestinal and hepatic P-gp and BCRP efflux transporters, increasing substrate exposure.
What to do
Monitor for adverse effects of the hepatitis C regimen such as headache, fatigue and GI upset. Consider the labeled dose reduction advice for transporter substrates if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as moderate. Danicopan and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-gp and BCRP and can raise plasma concentrations of sofosbuvir, velpatasvir and voxilaprevir, which are substrates of these transporters. Higher exposure may increase the risk of adverse effects from the hepatitis C regimen.
How serious is the interaction between Danicopan and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects of the hepatitis C regimen such as headache, fatigue and GI upset. Consider the labeled dose reduction advice for transporter substrates if toxicity occurs.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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