Drug interactions
Dantrolene + Dexchlorpheniramine
Severity: Moderate
Dantrolene and Dexchlorpheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene commonly causes drowsiness, dizziness and weakness, and the sedating antihistamine dexchlorpheniramine adds to these effects. Combined use can impair alertness, psychomotor performance and safety when driving or operating machinery.
What this interaction means in plain words
Dantrolene and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Dexchlorpheniramine belongs to Respiratory.
Why it happens
Additive central nervous system depression from two agents with sedative properties.
What to do
Warn patients about additive drowsiness and advise against driving or hazardous tasks until the response is known. Consider a non-sedating antihistamine if an antihistamine is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderate
- Amisulpride + Dexchlorpheniramine Moderate
- Amitriptyline + Dexchlorpheniramine Moderate
- Amobarbital + Dexchlorpheniramine Moderate
- Asenapine + Dexchlorpheniramine Moderate
- Azelastine-fluticasone + Dexchlorpheniramine Moderate
Frequently asked questions
Can I take Dantrolene with Dexchlorpheniramine?
MediHelp rates the interaction as moderate. Dantrolene and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dantrolene commonly causes drowsiness, dizziness and weakness, and the sedating antihistamine dexchlorpheniramine adds to these effects. Combined use can impair alertness, psychomotor performance and safety when driving or operating machinery.
How serious is the interaction between Dantrolene and Dexchlorpheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about additive drowsiness and advise against driving or hazardous tasks until the response is known. Consider a non-sedating antihistamine if an antihistamine is needed.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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