Drug interactions
Dantrolene + Difelikefalin
Severity: Moderate
Dantrolene and Difelikefalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin, a kappa opioid agonist, can cause somnolence and dizziness, and dantrolene has similar effects. Using them together may increase drowsiness and the risk of falls, especially in dialysis patients.
What this interaction means in plain words
Dantrolene and Difelikefalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Difelikefalin belongs to Dermatology.
Why it happens
Additive CNS depressant effects of two sedating drugs.
What to do
Monitor for excessive sedation, dizziness and falls, and counsel patients about driving. Reduce doses or review need if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Dantrolene with Difelikefalin?
MediHelp rates the interaction as moderate. Dantrolene and Difelikefalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difelikefalin, a kappa opioid agonist, can cause somnolence and dizziness, and dantrolene has similar effects. Using them together may increase drowsiness and the risk of falls, especially in dialysis patients.
How serious is the interaction between Dantrolene and Difelikefalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, dizziness and falls, and counsel patients about driving. Reduce doses or review need if sedation is troublesome.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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