Drug interactions
Dantrolene + Ethinyl estradiol-drospirenone
Severity: Moderate
Dantrolene and Ethinyl estradiol-drospirenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can affect the liver, and estrogens have been associated with higher hepatotoxicity risk with dantrolene in women. The CYP3A4 effect cited is not clinically meaningful.
What this interaction means in plain words
Dantrolene and Ethinyl estradiol-drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Ethinyl estradiol-drospirenone belongs to Endocrine.
Why it happens
Possible additive hepatotoxic potential; pharmacokinetic effect not established.
What to do
Monitor liver function tests during long-term dantrolene use and stop it if hepatic injury develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as moderate. Dantrolene and Ethinyl estradiol-drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can affect the liver, and estrogens have been associated with higher hepatotoxicity risk with dantrolene in women. The CYP3A4 effect cited is not clinically meaningful.
How serious is the interaction between Dantrolene and Ethinyl estradiol-drospirenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests during long-term dantrolene use and stop it if hepatic injury develops.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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