Drug interactions
Dantrolene + Etomidate
Severity: Moderate
Dantrolene and Etomidate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etomidate is an intravenous hypnotic anesthetic, and dantrolene can add to sedation and muscle weakness. The combination may prolong or deepen sedation and affect recovery.
What this interaction means in plain words
Dantrolene and Etomidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Etomidate belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation by etomidate and dantrolene sedation.
What to do
Titrate etomidate to effect and monitor airway, ventilation and recovery. Dantrolene itself should not be withheld when treating malignant hyperthermia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Dantrolene with Etomidate?
MediHelp rates the interaction as moderate. Dantrolene and Etomidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etomidate is an intravenous hypnotic anesthetic, and dantrolene can add to sedation and muscle weakness. The combination may prolong or deepen sedation and affect recovery.
How serious is the interaction between Dantrolene and Etomidate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate etomidate to effect and monitor airway, ventilation and recovery. Dantrolene itself should not be withheld when treating malignant hyperthermia.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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