Drug interactions
Dantrolene + Etravirine
Severity: Minor
Dantrolene and Etravirine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a weak to moderate inducer of CYP3A4 and may accelerate the metabolism of dantrolene, which is partly CYP3A4-dependent. This could lower dantrolene exposure and reduce its antispastic effect.
What this interaction means in plain words
Dantrolene and Etravirine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dantrolene belongs to Musculoskeletal; Etravirine belongs to Anti Virals.
Why it happens
Etravirine induces CYP3A4, potentially increasing dantrolene clearance.
What to do
Monitor spasticity control and adjust the dantrolene dose if efficacy falls.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dantrolene
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Dantrolene with Etravirine?
MediHelp rates the interaction as minor. Dantrolene and Etravirine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etravirine is a weak to moderate inducer of CYP3A4 and may accelerate the metabolism of dantrolene, which is partly CYP3A4-dependent. This could lower dantrolene exposure and reduce its antispastic effect.
How serious is the interaction between Dantrolene and Etravirine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor spasticity control and adjust the dantrolene dose if efficacy falls.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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