Drug interactions
Dantrolene + Haloperidol
Severity: Moderate
Dantrolene and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol can cause sedation and dantrolene commonly causes drowsiness, so their combination may increase central nervous system depression. Impaired alertness and coordination may result.
What this interaction means in plain words
Dantrolene and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Haloperidol belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Monitor for oversedation and falls, particularly in older patients. Adjust doses if daytime impairment develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Dantrolene with Haloperidol?
MediHelp rates the interaction as moderate. Dantrolene and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol can cause sedation and dantrolene commonly causes drowsiness, so their combination may increase central nervous system depression. Impaired alertness and coordination may result.
How serious is the interaction between Dantrolene and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and falls, particularly in older patients. Adjust doses if daytime impairment develops.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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