Drug interactions
Dantrolene + Hydromorphone
Severity: Moderate
Dantrolene and Hydromorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene can cause drowsiness, dizziness and weakness, which may add to the sedation caused by hydromorphone. Oral dantrolene may also affect respiratory muscle strength in susceptible patients.
What this interaction means in plain words
Dantrolene and Hydromorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Hydromorphone belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for sedation and respiratory function, and advise against driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Hydromorphone?
MediHelp rates the interaction as moderate. Dantrolene and Hydromorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dantrolene can cause drowsiness, dizziness and weakness, which may add to the sedation caused by hydromorphone. Oral dantrolene may also affect respiratory muscle strength in susceptible patients.
How serious is the interaction between Dantrolene and Hydromorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory function, and advise against driving until the response is known.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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