Drug interactions
Dantrolene + Hydroxyzine
Severity: Moderate
Dantrolene and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine is a sedating antihistamine and dantrolene often causes drowsiness. Combined use may increase sedation and reduce psychomotor performance.
What this interaction means in plain words
Dantrolene and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Hydroxyzine belongs to Respiratory.
Why it happens
Additive central nervous system depression from H1-antihistamine effects and dantrolene.
What to do
Monitor for excessive sedation and warn patients against driving. Use the lowest effective hydroxyzine dose, especially in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Dantrolene with Hydroxyzine?
MediHelp rates the interaction as moderate. Dantrolene and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine is a sedating antihistamine and dantrolene often causes drowsiness. Combined use may increase sedation and reduce psychomotor performance.
How serious is the interaction between Dantrolene and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and warn patients against driving. Use the lowest effective hydroxyzine dose, especially in older adults.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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