Drug interactions
Dantrolene + Iloperidone
Severity: Moderate
Dantrolene and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is a sedating antipsychotic and a weak time-dependent CYP3A inhibitor. It may add to dantrolene sedation and could modestly raise dantrolene exposure.
What this interaction means in plain words
Dantrolene and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Iloperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression plus possible CYP3A4 inhibition reducing dantrolene metabolism.
What to do
Monitor for drowsiness, dizziness, orthostasis and liver enzyme changes. Reduce the dantrolene dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Dantrolene with Iloperidone?
MediHelp rates the interaction as moderate. Dantrolene and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is a sedating antipsychotic and a weak time-dependent CYP3A inhibitor. It may add to dantrolene sedation and could modestly raise dantrolene exposure.
How serious is the interaction between Dantrolene and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness, dizziness, orthostasis and liver enzyme changes. Reduce the dantrolene dose if adverse effects emerge.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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