Drug interactions
Dantrolene + Lurasidone
Severity: Moderate
Dantrolene and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone can cause somnolence and dantrolene commonly causes drowsiness. Together, central nervous system depression and psychomotor impairment may be greater.
What this interaction means in plain words
Dantrolene and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Lurasidone belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Monitor for increased sedation and dizziness, particularly at initiation or after dose changes. Advise patients to avoid driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Dantrolene with Lurasidone?
MediHelp rates the interaction as moderate. Dantrolene and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone can cause somnolence and dantrolene commonly causes drowsiness. Together, central nervous system depression and psychomotor impairment may be greater.
How serious is the interaction between Dantrolene and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation and dizziness, particularly at initiation or after dose changes. Advise patients to avoid driving until the response is known.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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