Drug interactions
Dantrolene + Meperidine
Severity: Moderate
Dantrolene and Meperidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene can cause drowsiness and dizziness, and this may add to opioid sedation. Clinically important respiratory depression is mainly a concern with higher doses.
What this interaction means in plain words
Dantrolene and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Meperidine belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for excessive sedation and counsel patients on driving. Reduce doses if drowsiness is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Meperidine?
MediHelp rates the interaction as moderate. Dantrolene and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dantrolene can cause drowsiness and dizziness, and this may add to opioid sedation. Clinically important respiratory depression is mainly a concern with higher doses.
How serious is the interaction between Dantrolene and Meperidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and counsel patients on driving. Reduce doses if drowsiness is troublesome.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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