Drug interactions
Dantrolene + Midazolam
Severity: Moderate
Dantrolene and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam is a potent benzodiazepine sedative and dantrolene adds drowsiness. Combined use may deepen sedation and, at higher doses, contribute to respiratory depression.
What this interaction means in plain words
Dantrolene and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Midazolam belongs to Central Nervous System.
Why it happens
Additive central nervous system depression via GABA-A enhancement and dantrolene's sedative effect.
What to do
Titrate midazolam carefully and monitor sedation level, respiratory rate and oxygen saturation. Use reduced doses in elderly or frail patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Dantrolene with Midazolam?
MediHelp rates the interaction as moderate. Dantrolene and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midazolam is a potent benzodiazepine sedative and dantrolene adds drowsiness. Combined use may deepen sedation and, at higher doses, contribute to respiratory depression.
How serious is the interaction between Dantrolene and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate midazolam carefully and monitor sedation level, respiratory rate and oxygen saturation. Use reduced doses in elderly or frail patients.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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