Drug interactions
Dantrolene + Nabilone
Severity: Moderate
Dantrolene and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene commonly causes drowsiness, dizziness and weakness, and nabilone adds sedation and psychomotor impairment. Combined use may increase the risk of oversedation and falls.
What this interaction means in plain words
Dantrolene and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive central nervous system depression through pharmacodynamic synergy.
What to do
Titrate both drugs slowly and monitor sedation and muscle weakness. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Nabilone?
MediHelp rates the interaction as moderate. Dantrolene and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dantrolene commonly causes drowsiness, dizziness and weakness, and nabilone adds sedation and psychomotor impairment. Combined use may increase the risk of oversedation and falls.
How serious is the interaction between Dantrolene and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate both drugs slowly and monitor sedation and muscle weakness. Advise patients to avoid driving and alcohol.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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