Drug interactions
Dantrolene + Nisoldipine
Severity: Major
Dantrolene and Nisoldipine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cardiovascular collapse with marked hyperkalemia has been reported when dantrolene was given with calcium channel blockers, mostly non-dihydropyridines such as verapamil. Dihydropyridines like nisoldipine are thought to carry lower risk, but the data are limited.
What this interaction means in plain words
Dantrolene and Nisoldipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dantrolene belongs to Musculoskeletal; Nisoldipine belongs to Cardiovascular.
Why it happens
Not well established; possible additive effects on calcium handling and cardiac conduction with hyperkalemia.
What to do
Avoid the combination where possible, particularly with intravenous dantrolene. If needed, monitor ECG, blood pressure and serum potassium closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dantrolene
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Dantrolene with Nisoldipine?
MediHelp rates the interaction as major. Dantrolene and Nisoldipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cardiovascular collapse with marked hyperkalemia has been reported when dantrolene was given with calcium channel blockers, mostly non-dihydropyridines such as verapamil. Dihydropyridines like nisoldipine are thought to carry lower risk, but the data are limited.
How serious is the interaction between Dantrolene and Nisoldipine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, particularly with intravenous dantrolene. If needed, monitor ECG, blood pressure and serum potassium closely.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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