Drug interactions
Dantrolene + Perphenazine
Severity: Moderate
Dantrolene and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine is a sedating phenothiazine antipsychotic and dantrolene also causes drowsiness. The combination can increase sedation and impair alertness and coordination.
What this interaction means in plain words
Dantrolene and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Perphenazine belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Monitor for oversedation and falls, particularly in the elderly. Consider dose reduction of one agent if sedation interferes with function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Dantrolene with Perphenazine?
MediHelp rates the interaction as moderate. Dantrolene and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine is a sedating phenothiazine antipsychotic and dantrolene also causes drowsiness. The combination can increase sedation and impair alertness and coordination.
How serious is the interaction between Dantrolene and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and falls, particularly in the elderly. Consider dose reduction of one agent if sedation interferes with function.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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