Drug interactions
Dantrolene + Ribociclib
Severity: Moderate
Dantrolene and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate CYP3A4 inhibitor and could raise dantrolene exposure, since dantrolene is metabolized in the liver. This may increase dose-related effects such as muscle weakness, drowsiness and hepatotoxicity, although clinical data are lacking.
What this interaction means in plain words
Dantrolene and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibition of CYP3A4 may reduce hepatic and intestinal metabolism of dantrolene.
What to do
Monitor liver function tests and for excessive weakness or sedation when the combination is used. Reduce the dantrolene dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Dantrolene with Ribociclib?
MediHelp rates the interaction as moderate. Dantrolene and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate CYP3A4 inhibitor and could raise dantrolene exposure, since dantrolene is metabolized in the liver. This may increase dose-related effects such as muscle weakness, drowsiness and hepatotoxicity, although clinical data are lacking.
How serious is the interaction between Dantrolene and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and for excessive weakness or sedation when the combination is used. Reduce the dantrolene dose if adverse effects emerge.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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