Drug interactions
Dantrolene + Tapentadol
Severity: Moderate
Dantrolene and Tapentadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene can cause drowsiness, dizziness and muscle weakness, and these effects can add to the sedation caused by tapentadol. This can impair alertness and coordination.
What this interaction means in plain words
Dantrolene and Tapentadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Tapentadol belongs to Musculoskeletal.
Why it happens
Additive CNS depression and muscle weakness from opioid and dantrolene effects.
What to do
Monitor for excessive sedation and weakness, adjusting doses as needed. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tapentadol
- Calcium / magnesium / potassium / sodium oxybates + Tapentadol Contraindicated
- Isocarboxazid + Tapentadol Contraindicated
- Linezolid + Tapentadol Contraindicated
- Methylene blue + Tapentadol Contraindicated
- Olanzapine / samidorphan + Tapentadol Contraindicated
- Phenelzine + Tapentadol Contraindicated
Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Tapentadol?
MediHelp rates the interaction as moderate. Dantrolene and Tapentadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dantrolene can cause drowsiness, dizziness and muscle weakness, and these effects can add to the sedation caused by tapentadol. This can impair alertness and coordination.
How serious is the interaction between Dantrolene and Tapentadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and weakness, adjusting doses as needed. Advise patients to avoid driving and alcohol.
What other medicines interact with Tapentadol?
MediHelp also lists interactions of Tapentadol with, for example, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid, Linezolid. The full list is on the Tapentadol page.
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