Drug interactions
Dantrolene + Tazemetostat
Severity: Minor
Dantrolene and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak to moderate CYP3A4 inducer and may lower exposure to CYP3A4-metabolized drugs. Dantrolene is metabolized by the liver, so its effect could be reduced, but the clinical significance is uncertain.
What this interaction means in plain words
Dantrolene and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dantrolene belongs to Musculoskeletal; Tazemetostat belongs to Miscellaneous.
Why it happens
Induction of CYP3A4 by tazemetostat may increase dantrolene metabolism.
What to do
Monitor for reduced antispastic or antihyperthermic effect and adjust the dantrolene dose if response diminishes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dantrolene
Other interactions of Tazemetostat
Frequently asked questions
Can I take Dantrolene with Tazemetostat?
MediHelp rates the interaction as minor. Dantrolene and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak to moderate CYP3A4 inducer and may lower exposure to CYP3A4-metabolized drugs. Dantrolene is metabolized by the liver, so its effect could be reduced, but the clinical significance is uncertain.
How serious is the interaction between Dantrolene and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antispastic or antihyperthermic effect and adjust the dantrolene dose if response diminishes.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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