Drug interactions
Dapagliflozin + Insulin degludec-insulin aspart
Severity: Moderate
Dapagliflozin and Insulin degludec-insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dapagliflozin added to insulin increases glucose lowering and the risk of hypoglycemia. SGLT2 inhibitors with insulin also carry a risk of euglycemic ketoacidosis, especially if insulin is reduced excessively or omitted.
What this interaction means in plain words
Dapagliflozin and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin belongs to Endocrine; Insulin degludec-insulin aspart belongs to Endocrine.
Why it happens
Additive glucose lowering via insulin action plus SGLT2-mediated urinary glucose excretion.
What to do
Consider a modest insulin dose reduction when starting dapagliflozin and monitor blood glucose. Check ketones in unwell patients and withhold dapagliflozin during acute illness or fasting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Dapagliflozin
- Chlorpropamide + Dapagliflozin Moderate
- Dapagliflozin + Gliclazide Moderate
- Dapagliflozin + Glimepiride Moderate
- Dapagliflozin + Glimepiride-pioglitazone Moderate
- Dapagliflozin + Glipizide Moderate
- Dapagliflozin + Glipizide-metformin Moderate
Frequently asked questions
Can I take Dapagliflozin with Insulin degludec-insulin aspart?
MediHelp rates the interaction as moderate. Dapagliflozin and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapagliflozin added to insulin increases glucose lowering and the risk of hypoglycemia. SGLT2 inhibitors with insulin also carry a risk of euglycemic ketoacidosis, especially if insulin is reduced excessively or omitted.
How serious is the interaction between Dapagliflozin and Insulin degludec-insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a modest insulin dose reduction when starting dapagliflozin and monitor blood glucose. Check ketones in unwell patients and withhold dapagliflozin during acute illness or fasting.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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