Drug interactions
Dapagliflozin-metformin + Leuprolide
Severity: Minor
Dapagliflozin-metformin and Leuprolide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
GnRH agonists such as leuprolide can reduce insulin sensitivity and worsen glycemic control during long-term therapy. The effect is gradual and generally modest.
What this interaction means in plain words
Dapagliflozin-metformin and Leuprolide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapagliflozin-metformin belongs to Endocrine; Leuprolide belongs to Endocrine.
Why it happens
Sex hormone suppression increases insulin resistance, opposing antidiabetic effects.
What to do
Monitor HbA1c and glucose periodically during leuprolide therapy and intensify antidiabetic treatment as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Dapagliflozin-metformin with Leuprolide?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Leuprolide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. GnRH agonists such as leuprolide can reduce insulin sensitivity and worsen glycemic control during long-term therapy. The effect is gradual and generally modest.
How serious is the interaction between Dapagliflozin-metformin and Leuprolide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HbA1c and glucose periodically during leuprolide therapy and intensify antidiabetic treatment as needed.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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