Drug interactions
Dapagliflozin-metformin + Pacritinib
Severity: Moderate
Dapagliflozin-metformin and Pacritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pacritinib may inhibit hepatic uptake of metformin via OCT1, increasing plasma concentrations. Higher metformin exposure could increase gastrointestinal effects and the risk of lactic acidosis, although hepatic uptake inhibition may also alter glucose-lowering effect.
What this interaction means in plain words
Dapagliflozin-metformin and Pacritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Pacritinib belongs to Oncology.
Why it happens
Pacritinib inhibits OCT1, altering hepatic uptake and clearance of metformin.
What to do
Monitor blood glucose and for metformin adverse effects when starting pacritinib. Reduce the metformin dose if intolerance or excessive exposure is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Dapagliflozin-metformin with Pacritinib?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Pacritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pacritinib may inhibit hepatic uptake of metformin via OCT1, increasing plasma concentrations. Higher metformin exposure could increase gastrointestinal effects and the risk of lactic acidosis, although hepatic uptake inhibition may also alter glucose-lowering effect.
How serious is the interaction between Dapagliflozin-metformin and Pacritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and for metformin adverse effects when starting pacritinib. Reduce the metformin dose if intolerance or excessive exposure is suspected.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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