Drug interactions
Dapagliflozin-metformin + Pentamidine
Severity: Moderate
Dapagliflozin-metformin and Pentamidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentamidine can cause pancreatic beta-cell toxicity leading to hypoglycemia followed by hyperglycemia or diabetes. This can disrupt control in patients on antidiabetic drugs.
What this interaction means in plain words
Dapagliflozin-metformin and Pentamidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Pentamidine belongs to Anti Parasitic.
Why it happens
Pentamidine is toxic to pancreatic beta cells, causing insulin release then insulin deficiency.
What to do
Monitor blood glucose during and after pentamidine therapy and adjust antidiabetic drugs accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
Frequently asked questions
Can I take Dapagliflozin-metformin with Pentamidine?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Pentamidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentamidine can cause pancreatic beta-cell toxicity leading to hypoglycemia followed by hyperglycemia or diabetes. This can disrupt control in patients on antidiabetic drugs.
How serious is the interaction between Dapagliflozin-metformin and Pentamidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during and after pentamidine therapy and adjust antidiabetic drugs accordingly.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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