Drug interactions
Dapagliflozin-metformin + Prochlorperazine
Severity: Minor
Dapagliflozin-metformin and Prochlorperazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines such as prochlorperazine may raise blood glucose and impair glucose tolerance, reducing antidiabetic effect. With short-term antiemetic use the effect is usually small.
What this interaction means in plain words
Dapagliflozin-metformin and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapagliflozin-metformin belongs to Endocrine; Prochlorperazine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism through phenothiazine-related reduced insulin secretion and insulin resistance.
What to do
Monitor blood glucose during prolonged or high-dose use and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Dapagliflozin-metformin with Prochlorperazine?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenothiazines such as prochlorperazine may raise blood glucose and impair glucose tolerance, reducing antidiabetic effect. With short-term antiemetic use the effect is usually small.
How serious is the interaction between Dapagliflozin-metformin and Prochlorperazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during prolonged or high-dose use and adjust antidiabetic therapy if control worsens.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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