Drug interactions
Dapsone + Digoxin
Severity: Minor
Dapsone and Digoxin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotic effects on gut flora can increase digoxin absorption in patients who convert it via Eggerthella lenta. Dapsone has limited antibacterial activity against such flora, so any effect is minor and poorly documented.
What this interaction means in plain words
Dapsone and Digoxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapsone belongs to Anti Bacterial; Digoxin belongs to Cardiovascular.
Why it happens
Possible alteration of gut bacteria that inactivate digoxin, raising its bioavailability.
What to do
No routine adjustment is needed; check digoxin levels if signs of toxicity appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Dapsone with Digoxin?
MediHelp rates the interaction as minor. Dapsone and Digoxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotic effects on gut flora can increase digoxin absorption in patients who convert it via Eggerthella lenta. Dapsone has limited antibacterial activity against such flora, so any effect is minor and poorly documented.
How serious is the interaction between Dapsone and Digoxin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; check digoxin levels if signs of toxicity appear.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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