Drug interactions
Dapsone + Estradiol
Severity: Minor
Dapsone and Estradiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reduced estrogen reabsorption through altered gut flora has been proposed with antimicrobials, but this is poorly supported and dapsone has little relevant antibacterial effect. Clinically significant loss of estrogen effect is unlikely.
What this interaction means in plain words
Dapsone and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapsone belongs to Anti Bacterial; Estradiol belongs to Endocrine.
Why it happens
Theoretical alteration of gut flora affecting enterohepatic recycling of estrogen; not established.
What to do
No action is generally required; counsel the patient to report breakthrough bleeding or loss of symptom control.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Dapsone with Estradiol?
MediHelp rates the interaction as minor. Dapsone and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Reduced estrogen reabsorption through altered gut flora has been proposed with antimicrobials, but this is poorly supported and dapsone has little relevant antibacterial effect. Clinically significant loss of estrogen effect is unlikely.
How serious is the interaction between Dapsone and Estradiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally required; counsel the patient to report breakthrough bleeding or loss of symptom control.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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