Drug interactions
Dapsone + Hydroxychloroquine
Severity: Moderate
Dapsone and Hydroxychloroquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dapsone can cause dose-related hemolysis and methemoglobinemia, particularly in patients with G6PD deficiency. Hydroxychloroquine can also cause hemolysis in G6PD-deficient patients, so combined use may add to the hematologic risk.
What this interaction means in plain words
Dapsone and Hydroxychloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapsone belongs to Anti Bacterial; Hydroxychloroquine belongs to Musculoskeletal.
Why it happens
Additive oxidative stress on red blood cells, mainly in G6PD-deficient patients; the interaction is not fully characterized.
What to do
Check G6PD status before combined use. Monitor hemoglobin and signs of hemolysis or methemoglobinemia, and stop one agent if hemolysis develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Frequently asked questions
Can I take Dapsone with Hydroxychloroquine?
MediHelp rates the interaction as moderate. Dapsone and Hydroxychloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapsone can cause dose-related hemolysis and methemoglobinemia, particularly in patients with G6PD deficiency. Hydroxychloroquine can also cause hemolysis in G6PD-deficient patients, so combined use may add to the hematologic risk.
How serious is the interaction between Dapsone and Hydroxychloroquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check G6PD status before combined use. Monitor hemoglobin and signs of hemolysis or methemoglobinemia, and stop one agent if hemolysis develops.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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