Drug interactions
Dapsone + Idelalisib
Severity: Moderate
Dapsone and Idelalisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and may increase dapsone exposure. Higher dapsone levels increase hemolysis and methemoglobinemia risk. This matters because both drugs are used in patients prone to infection and anemia.
What this interaction means in plain words
Dapsone and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapsone belongs to Anti Bacterial; Idelalisib belongs to Oncology.
Why it happens
Idelalisib inhibits CYP3A4, reducing dapsone metabolism.
What to do
Monitor complete blood count and methemoglobin, and reduce the dapsone dose if toxicity appears. Consider alternative PJP prophylaxis if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Dapsone with Idelalisib?
MediHelp rates the interaction as moderate. Dapsone and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib is a strong CYP3A inhibitor and may increase dapsone exposure. Higher dapsone levels increase hemolysis and methemoglobinemia risk. This matters because both drugs are used in patients prone to infection and anemia.
How serious is the interaction between Dapsone and Idelalisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood count and methemoglobin, and reduce the dapsone dose if toxicity appears. Consider alternative PJP prophylaxis if needed.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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