Drug interactions
Dapsone + Levoketoconazole
Severity: Moderate
Dapsone and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and may substantially raise dapsone exposure. This could increase hemolysis and methemoglobinemia, particularly in G6PD-deficient patients.
What this interaction means in plain words
Dapsone and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapsone belongs to Anti Bacterial; Levoketoconazole belongs to Endocrine.
Why it happens
Levoketoconazole strongly inhibits CYP3A4, reducing dapsone clearance.
What to do
Monitor CBC, methemoglobin and symptoms closely; reduce the dapsone dose if toxicity develops, or choose an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Dapsone with Levoketoconazole?
MediHelp rates the interaction as moderate. Dapsone and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong CYP3A4 inhibitor and may substantially raise dapsone exposure. This could increase hemolysis and methemoglobinemia, particularly in G6PD-deficient patients.
How serious is the interaction between Dapsone and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor CBC, methemoglobin and symptoms closely; reduce the dapsone dose if toxicity develops, or choose an alternative.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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