Drug interactions
Dapsone + Nevirapine
Severity: Minor
Dapsone and Nevirapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine induces CYP3A4 and may reduce dapsone concentrations. Both drugs can cause hypersensitivity and skin reactions, which complicates attributing rashes when used together.
What this interaction means in plain words
Dapsone and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapsone belongs to Anti Bacterial; Nevirapine belongs to Anti Virals.
Why it happens
Induction of CYP3A4 by nevirapine may increase dapsone clearance.
What to do
Monitor clinical response to dapsone (for example PCP prophylaxis efficacy) and evaluate any new rash promptly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Dapsone with Nevirapine?
MediHelp rates the interaction as minor. Dapsone and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nevirapine induces CYP3A4 and may reduce dapsone concentrations. Both drugs can cause hypersensitivity and skin reactions, which complicates attributing rashes when used together.
How serious is the interaction between Dapsone and Nevirapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to dapsone (for example PCP prophylaxis efficacy) and evaluate any new rash promptly.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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